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Correspondence to So Young Kwon, M. Thyroid function and autoantibodies were measured at baseline, and virologic response and thyroid function were assessed every 3 months during therapy. Results: TD developed in 67 patients
The objective was to study the molecular basis of severe congenital hypothyroidism, using the next generation sequencing NGS and the recent guidelines for assessment of sequence variants. The majority of variants identified in DH genes were monoallelic. In contrast to earlier studies demonstrating the predominance of TD in severe CH, the majority of variants identified in our study were in DH genes.
MIFTS : Hypothyroidism Categories : Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases. Expand all tables.
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Calibrators and samples react with the capture monoclonal antibody MAb 1 coated on microtiter well and with a monoclonal antibody MAb 2 labelled with horseradish peroxidase HRP. Bound enzyme-labelled antibody is measured through a chromogenic reaction. Chromogenic solution TMB is added and incubated.
If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. In target tissues, T 3 interacts with nuclear T 3 receptors that are, in turn, bound to special nucleotide sequences in the promoter regions of genes that are positively or negatively regulated by thyroid hormone. In addition, the thyroid contains parafollicular or C cells that produce calcitonin, a amino-acid polypeptide that inhibits bone resorption, but has no apparent physiologic role in humans.
This application is a divisional application of U. Provisional Patent Application Ser. The present application is being filed along with a Sequence Listing in electronic format.
It may present with hypothyroidism or hyperthyroidism and with or without a goiter. The symptoms may vary depending on the thyroid function, i. Hyperthyroidism can cause sweating, rapid heart rate, anxiety, tremors, fatigue, difficulty sleeping, sudden weight loss, and protruding eyes. Symptoms may come and go depending on whether the person receives treatment, and whether the treatment takes effect.