Among the FusOnC2 consortium cancers of interest, synovial sarcoma has the highest incidence in the United States and worldwide, but has been a specifically underserved malignancy due to its predilection for the adolescent and young adult population and its relatively poor responsiveness to systemic therapy, compared to other pediatric sarcomas that also associate with fusion oncogenes. While much of the biology of SSSSX remains unknown and synovial sarcoma patients represent a clearly underserved, orphan-disease population, there are two principles at the extremes of the cancer biology spectrum that are well established. These discovery biology and therapeutic target identification efforts will be supported by two shared resource cores that will provide human validation of therapeutic targets and preclinical testing of therapeutic strategies.
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Oncotarget a primarily oncology-focused, peer-reviewed, open access, weekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases.
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Most pneumonia occurs when a breakdown in your body's natural defenses allows germs to invade and multiply within your lungs. To destroy the attacking organisms, white blood cells rapidly accumulate. Along with bacteria and fungi, they fill the air sacs within your lungs alveoli. Breathing may be labored.
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